Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts
- Creator: Blokland, Kaj E. C. , Nizamoglu, Mehmet , Habibie, Habibie , Borghuis, Theo , Schuliga, Michael , Melgert, Barbro N. , Knight, Darryl A. , Brandsma, Corry-Anke , Pouwels, Simon D. , Burgess, Janette K.
- Resource Type: journal article
- Date: 2022
A cGAS-dependent response links DNA damage and senescence in alveolar epithelial cells: a potential drug target in IPF
- Creator: Schuliga, Michael , Kanwal, Amama , Read, Jane , Blokland, Kaj E. C. , Burgess, Janette K. , Prele, Cecilia M. , Mutsaers, Steven E. , Grainge, Christopher , Thomson, Claire , James, Allen , Bartlett, Nathan W. , Knight, Darryl A.
- Resource Type: journal article
- Date: 2021
A senescence bystander effect in human lung fibroblasts
- Creator: Waters, David W. , Schuliga, Michael , Mutsaers, Steven E. , Grainge, Christopher L. , Knight, Darryl A. , Pathinayake, Prabuddha S. , Wei, Lan , Tan, Hui-Ying , Blokland, Kaj E. C. , Jaffar, Jade , Westall, Glen P. , Burgess, Janette K. , Prele, Cecilia M.
- Resource Type: journal article
- Date: 2021
Regulation of cellular senescence is independent from profibrotic fibroblast-deposited ECM
- Creator: Blokland, Kaj E. C. , Habibie, Habibie , Borghuis, Theo , Teitsma, Greta J. , Schuliga, Michael , Melgert, Barbro N. , Knight, Darryl A. , Brandsma, Corry-Anke , Pouwels, Simon D. , Burgess, Janette K.
- Resource Type: journal article
- Date: 2021
Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases
- Creator: Blokland, Kaj E. C. , Pouwels, Simon D. , Schuliga, Michael , Knight, Darryl A. , Burgess, Janette K.
- Resource Type: journal article
- Date: 2020
Self DNA perpetuates IPF lung fibroblast senescence in a cGAS-dependent manner
- Creator: Schuliga, Michael , Read, Jane , Blokland, Kaj E. C. , Waters, David W. , Burgess, Janette , Prele, Cecilia , Mutsaers, Steven E. , Jaffar, Jade , Westall, Glen , Reid, Andrew , James, Allen , Grainge, Christopher , Knight, Darryl A.
- Resource Type: journal article
- Date: 2020
Senescence of IPF lung fibroblasts disrupt alveolar epithelial cell proliferation and promote migration in wound healing
- Creator: Blokland, Kaj E. C. , Waters, David W. , Burgess, Janette K. , Knight, Darryl A. , Schuliga, Michael , Read, Jane , Pouwels, Simon D. , Grainge, Christopher L. , Jaffar, Jade , Westall, Glen , Mutsaers, Steven E. , Prele, Cecilia M.
- Resource Type: journal article
- Date: 2020
Extracellular vesicles in lung health, disease, and therapy
- Creator: McVey, Mark J. , Maishan, Mazharul , Blokland, Kaj E. C. , Bartlett, Nathan , Kuebler, Wolfgang M.
- Resource Type: journal article
- Date: 2019
STAT3 regulates the onset of oxidant-induced senescence in lung fibroblasts
- Creator: Waters, David W. , Blokland, Kaj E. C. , Pathinayake, Prabuddha S. , Wei, Lan , Schuliga, Michael , Jaffar, Jade , Westall, Glen P. , Hansbro, Philip M. , Prele, Cecilia M. , Mutsaers, Steven E. , Bartlett, Nathan W. , Burgess, Janette K. , Grainge, Christopher L. , Knight, Darryl A.
- Resource Type: journal article
- Date: 2019
Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis
- Creator: Waters, David W. , Blokland, Kaj E. C. , Pathinayake, Prabuddha S. , Burgess, Janette K. , Mutsaers, Steven E. , Prele, Cecilia M. , Schuliga, Michael , Grainge, Christopher L. , Knight, Darryl A.
- Resource Type: journal article
- Date: 2018
Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts
- Creator: Schuliga, Michael , Pechkovsky, Dmitri V. , Mutsaers, Steven E. , Jaffar, Jade , Westall, Glen , Grainge, Christopher , Knight, Darryl A. , Read, Jane , Waters, David W. , Blokland, Kaj E. C. , Reid, Andrew T. , Hogaboam, Cory M. , Khalil, Nasreen , Burgess, Janette K. , Prêle, Cecilia M.
- Resource Type: journal article
- Date: 2018